I got a "Intel® NUC Kit D54250WYK" and a harmony remote and I can power it on through the IR and in Windows 8.1 64bit I can navigate through the IR BUT not power off.
I install the "SIO_CIR_win8_20130716_2.9.1007" driver but no lucks
I tested the remote on a friends NUC D54250WYK and it works fine